17, 2021, the World Health Organization ( WHO) granted Emergency Use Listing for Novavax's NVX‑CoV2373 ( CovoVax) vaccine manufactured and marketed by Serum Institute of India Pvt. Next, the spike proteins are harvested and assembled onto a synthetic lipid nanoparticle of about 50 nanometers, each displaying up to 14 spike proteins. "No human fetal-derived cell lines or tissue, including HEK293 cells, are used to develop, manufacture, or produce NVX-CoV2373," a Novavax spokesperson told Religion News Service on Feb. 8, 2022. The baculovirus then infects a culture of Sf9 moth cells, which generate and display the spike protein on their cell membranes. For example, the COVID-19 vaccine creates an engineered baculovirus containing a modified coronavirus spike protein gene. Novavax Inc.'s vaccines are genetically engineered using three-dimensional nanostructures of recombinant proteins critical to disease pathogenesis. Matrix-M adjuvant has demonstrated a potent and well-tolerated effect by stimulating the entry of antigen-presenting cells into the injection site and enhancing antigen presentation in local lymph nodes, boosting immune response and helping an immunized person make antibodies against the coronavirus. The COVID-19 (SARS-CoV-2 rS [Recombinant, adjuvanted)) the vaccine was created using Novavax's proprietary nanoparticle technology, Matrix-M™, an adjuvant to enhance immune responses and stimulate high levels of neutralizing antibodies. Novavax COVID-19 Vaccine Adjuvanted ( Nuvaxovid™, CovoVax™, NVX-CoV2373) was the first protein-based vaccine engineered from the genetic sequence of the SARS-CoV-2 beta coronavirus. Novavax COVID-19 Vaccine Adjuvanted (Nuvaxovid, CovoVax, NVX-CoV2373)
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